Heart And Blood Circulation Problems
Cardiovascular autonomic neuropathy is a potentially serious heart and blood circulation problem thatâs common in people with diabetic polyneuropathy.
CAN happens when damage to the peripheral nerves disrupts the automatic functions that control your blood circulation and heartbeat.
The 2 main noticeable symptoms of CAN are:
- an inability to exercise for more than a very short period of time
- low blood pressure that can make you feel dizzy or faint when you stand up
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Zinc Carnosine And Helicobacter Pylori
H. pylori overgrowth is commonly behind the development of gastric ulcers. The H. pylori organism naturally degrades mucosal tissue in order to burrow itself into the stomach lining. Overgrowth of the organism leads to excess degeneration of the stomach lining and ulcers develop.
A prospective randomized clinical trial published in 2017 showed that when antibiotic treatment for H. pylori infection was combined with zinc carnosine the eradication rate was improved without added toxicity . A smaller trial published in 1999 reflected similar findings .
How To Take It
You should take zinc with water or juice. If zinc causes stomach upset, it can be taken with meals. Don’t take zinc at the same time as iron or calcium supplements.
A strong relationship exists between zinc and copper. Too much of one can cause a deficiency in the other. If you take zinc, including zinc in a multivitamin, you should also take copper.
Do not give zinc supplements to a child without talking to your doctor.
Daily intake of dietary zinc are listed below:
Pediatric
- Infants birth – 6 months: 2 mg
- Infants 7 – 12 months: 3 mg
- Children 1 – 3 years: 3 mg
- Children 4 – 8 years: 5 mg
- Children 9 – 13 years: 8 mg
- Boys 14 – 18 years: 11 mg
- Girls 14 – 18 years: 9 mg
Adult
- Men 19 years and older: 11 mg
- Women 19 years and older: 8 mg
- Pregnant women 14 – 18 years: 12 mg
- Pregnant women 19 years and older: 11 mg
- Breastfeeding women 14 – 18 years: 13 mg
- Breastfeeding women 19 years and older: 12 mg
You should not take high doses of zinc for more than a few days unless your doctor tells you to. Talk to your doctor before taking more than 40 mg of zinc per day and take breaks from zinc supplementation. During those breaks, get zinc from a well-balanced diet.
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How Do I Take Care Of My Foot And Toe Ulcers
Your healthcare provider might teach you how to care for your ulcers at home. You might be instructed to:
- Wash the affected area with mild soap.
- Keep the wound clean and dry.
- Change the bandages as directed.
- Take prescribed medications as directed.
- Drink plenty of fluids. Ask your healthcare provider how much water you should drink every day.
- Follow a healthy diet, as recommended by your healthcare provider.
- Exercise regularly, under your healthcare providers care.
- Wear appropriate shoes.
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Do You Have An Ulcer Or Heartburn
Stomach ulcers are painful open sores that develop on the lining of the stomach and small intestine. These open sores are getting worse by your stomach acid, but are usually not caused by the acid itself.
A great majority of ulcers are caused primarily by an infection of a bacterium called Helicobacter pylori . They also develop as a result of many factors, including the use of certain medications, as well as lifestyle and dietary factors.
Ulcers are treated through changes in lifestyle, medications, antibiotics and surgery, and this article will discuss natural alternatives for treating stomach ulcers.
The most common symptom of ulcers is burning pain that can be felt anywhere from the top of the sternum all the way down to the navel. Other symptoms include pain that wakes you up at night, or a pain 2-3 hours after eating and mild nausea that may go away with vomiting
Heartburn, on the other hand, is a painful burning sensation just below or behind the breastbone. It usually comes from the esophagus which is located in the upper central region of the abdomen. The pain often occurs in your chest and may spread to your neck or throat and can also be accompanied with a bitter taste in mouth.
Normally when food or liquid enters your stomach, muscles at the end of your esophagus close off this area. If these muscles dont close tightly enough, stomach acid can escape into the esophagus. This partly digested substance can cause heartburn and other symptoms.
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Connection Between Bulimia And Stomach Ulcers
One medical report specifically on stomach ulcers was written in 1989 and appeared in the medical journal Gastrointestinal Endoscopy. The authors state that in 1989, bulimia nervosa was recognized with increasing frequency whereas this wasnât the case in the previous years.
In the 37 patients with long-standing bulimia nervosa that were studied, the doctors did an endoscopic procedure to view the upper GI mucosa. This is where a camera captures what exactly is happening inside the body via a long tube that is inserted with a camera lens at the end of it. The mucosa in the stomach and esophagus was normal in 23 of the 37 patients or 62% of them.
Six patients or 16% of the patients had redness in the stomach or duodenum but none showed actual ulcers, erosions or bleeding. The researchers stated that in contrast to reports by others, the mucosal injury is limited to the esophagus, not the stomach.
Both groups of patients showed a significant reduction in the number of objective and subjective binge eating episodes. Monitoring the copper/zinc ratio, they found the numbers went from 1.4 to 1.1 in both conditions. All patients had multiple zinc deficiency related symptoms initially that improved with the treatment. Overall, the effectiveness was less in bulimia nervosa than the patients with binge eating disorder and there were only minor side effects.
Assessing Malondialdehyde Levels Gastric Enzyme Activity And Nitric Oxide Levels In The Gastric Tissue
To estimate the degree of lipid peroxidation caused by the acidified ethanol , the MDA contents of the stomach tissue homogenates were determined by means of the thiobarbituric acid assay, which was conducted according to the protocol outlined in the manual of the Cayman kit , in the section on in vitro assessment. MDA is a marker of cellular oxidative stress.
The gastric content of the endogenous enzymes superoxide dismutase and CAT were assayed according to the procedures supplied with the Cayman kits . The activity of PGE2 collected from the gastric tissue was assessed using 96-well microplates pre-coated with a monoclonal antibody specific to PGE2 according to the instructions supplied with the immunosorbent assay kit .
NO levels in the stomachs were determined by homogenizing 1g of stomach tissue. The supernatant was collected and assayed using Griess reagent according to the protocol provided with the Cayman kits . The nitrate±nitrite concentration in the gastric tissues was quantitated in units of M/g tissue based on a nitrate standard curve plotted at 540nm.
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Where Does An Ulcer Appear
There are many different kinds of ulcers. While peptic ulcers form in the stomach or upper intestine lining, ulcers can also occur almost anywhere on the body.
Ulcers that are found outside the body can include leg and foot ulcers. These ulcers are generally swollen or tender and can cause itchiness or pain. Skin discoloration and changes in texture are also common in ulcers found outside the body.
Whether they are found inside or on the skinâs surface, ulcers are sores that are often slow to heal. Once they have disappeared, ulcers can return if not treated properly. Depending on the cause of the ulcers, they can require different treatment options.
In Vivo Experiments And Acute Toxicity Testing
Sprague Dawley female rats were used for the acute toxicity study and seven groups of 6 Sprague Dawley male rats were used in the gastro-protective study. The rats were cared for in the animal house of the Faculty of Medicine, University of Malaya, Kuala Lumpur. All experimental protocols were carried out in accordance with the ethical guidelines and approved by the National Ethics Committee ) and following the criteria specified in the Guide for the Care and Use of Laboratory Animals.
To identify the maximum safe dosage of the complex, eighteen female rats were randomly allocated into 3 groups: a vehicle group treated with a 0.5% w/v solution of CMC at 5mL/kg as well as low- and high-dose groups treated with ZnSCN solutions at 50 and 500mg/kg according to OECD guidelines. The animals were deprived of food overnight immediately before the administration of the treatments. The animals were examined 2, 4, 8, 24 and 48h after the treatment for periods of 30minutes each to evaluate their clinical and toxicological status. The treated animals were kept for a period of 2 weeks and then anaesthetized with ketamine and xylazine after which their blood was collected for haematological and biochemical studies via the cardiac puncture technique. The animals were then euthanized by injection with xylazine and ketamine , after which their kidneys and livers were collected for histological examination.
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Signs You Have A Stomach Ulcer And Natural Remedies
As many as 1 out of every 10 people in the US and other western countries will experience a stomach ulcer at some point in their lives.
These irritating and often painful sores in the esophagus, stomach, and small intestine can be easy to treat, but if not addressed, can cause serious health problems.
The stomach and small intestine have protective mucus that lines them and keeps them safe from erosion from the very acid we need for healthy digestion. Ulcers happen when something weakens or alters this mucus coating, and the tissues become damaged from exposure to acid.
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The Gastrointestinal Domino Effect
The acidity of the stomach is beneficial because it acts as a primary defense against infection and assists in the early stages of digestion.
The body protects its own delicate tissues from harsh stomach acid with systems that require precise balance.
The first defense mechanism is specialized surface cells in the stomachs lining that secrete a heavy coating of protective mucus. Second, a rapid cell-turnover in the lining itself keeps fresh cells always at the ready.
If the bodys natural defenses against stomach acids become disrupted, it can result in stomach disorders such as painful gastritis and peptic ulcer disease.11-14
Gastritis is inflammation of the stomach lining. It doesnt always produce symptoms, but when symptoms do arise they can include abdominal pain, nausea, vomiting, and indigestion.11 Such symptoms are generally written off as an annoyance. In reality, these episodes leave lasting damage that eventually leads to mucosal damage and inflammation.11-13
While this process can be triggered by a host of factors, one of the most common causes is infection with theH. pylori bacterium.
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Znscn Elevated The Acidity Of The Gastric Juices And Gwm And Reduced The Ulcer Area
In experimental animals pretreated with OMP, ZnSCN at 20, 40 and 80mg/kg, the pH of the gastric contents increased significantly compared to the control group. Low doses of ZnSCN did not imply the same increase in pH level . The impact of ZnSCN on gastric acidity was dose-dependent.
Figure 7: Effect of ZnSCN on the gastric pH for the rats from all of the experimental groups.
Data are presented in the form of Mean ±SEM. *P< 0.001 vs ulcer control HCl/EtOH. **P< 0.001 vs normal. Carboxymethyl cellulose acidified ethanol omeprazole and SCN) 2-morpholino-N– ethanamine-k3N,N,N bis zin .
The effect of ZnSCN on the ulcer area induced by HCl/Ethanol is shown in . The ulcer areas seen in the rats treated with ZnSCN were significantly lower than those in the ulcer group, with the highest dose group having a limited ulcer area. The rats treated with the lowest ZnSCN dose did not show any significant change in the ulcer area compared to the ulcer group. The sizes of the ulcer areas decreased as the dosage of ZnSCN increased .
Figure 8: Effect of ZnSCN on the gastric wall mucus , gastric ulcer area and inhibition area % for rats from all the experimental groups.
All values are displayed as Mean ±SEM. *P< 0.05 vs ulcer control HCl/EtOH. **P< 0.05 vs normal. #P< 0.05 vs OMP-treated group. Gastric lesions inhibition % is recorded above the bars. Carboxymethyl cellulose acidified ethanol omeprazole and SCN) 2-morpholino-N– ethanamine-k3N,N,N bis zin .
Special Precautions & Warnings
Infants and childrenLIKELY SAFEPOSSIBLY UNSAFE
Pregnancy and breast-feeding: Zinc is LIKELY SAFE for most pregnant and breast-feeding women when used in the recommended daily amounts . However, zinc is POSSIBLY UNSAFE when used in high doses by breast-feeding women and LIKELY UNSAFE when used in high doses by pregnant women. Pregnant women over 18 should not take more than 40 mg of zinc per day pregnant women age 14 to 18 should not take more than 34 mg per day. Breast-feeding women over 18 should not take more than 40 mg of zinc per day breast-feeding women age 14 to 18 should not take more than 34 mg per day.
Alcoholism: Long-term, excessive alcohol drinking is linked to poor zinc absorption in the body.
Diabetes: Large doses of zinc can lower blood sugar in people with diabetes. People with diabetes should use zinc products cautiously.
Hemodialysis: People receiving hemodialysis treatments seem to be at risk for zinc deficiency and might require zinc supplements.
HIV /AIDS: Use zinc cautiously if you have HIV/AIDS. Zinc use has been linked to shorter survival time in people with HIV/AIDs.
Syndromes in which it is difficult for the body to absorb nutrients: People with malabsorption syndromes may be zinc deficient.
Rheumatoid arthritis : People with RA absorb less zinc.
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What Are Stomach Ulcers
Stomach ulcers are sores on the lining of the stomach. The two different types of stomach ulcers are peptic ulcers and duodenal ulcers. A peptic ulcer is also called a gastric ulcer. A duodenal ulcer is one that happens on the upper part of the small intestine, which is called the duodenum.
Stomach ulcers are not caused by stress and spicy foods, although these may worsen ulcers. They are caused by Helicobacter pylori bacterial infection and long-term use of ibuprofen and naproxen.
Stomach acid is produced by cells in your stomach lining. This acid is made of hydrochloric acid, potassium chloride and sodium chloride and it is highly acidic . Battery acid is pH 0.0 and dissolves metal and bone. The pH of stomach acid is strong enough to damage bones and teeth.
Mucus lines the inside of the stomach and protects it from the stomach acids.
Open Sores And Wounds
Having high blood sugar for a long time can lead to poor circulation and nerve damage. You may have developed these if youve had uncontrolled diabetes for a long time.
Poor circulation and nerve damage can make it hard for your body to heal wounds. This is especially true on the feet. These open wounds are called diabetic ulcers.
Diabetes and feet
- Get immediate medical care for an open sore or wound.
- Work with your doctor to better control your diabetes.
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What Is Vitamin U
Vitamin U, or methylmethionine sulfonium chloride , is found in raw cabbage juice. Its been used in medical studies for healing peptic ulcers, providing rapid relief from pain as well as healing to the compromised tissue. The first medical study of this kind was done back in 1949 with shockingly excellent results. Many of these patients couldnt have surgery but a quart of cabbage juice each day for 2-3 weeks, or dehydrated cabbage juice, healed them!
Of the 92 patients with ulcer pain 86 of them were pain-free within 3.92 days!, on average. Thats a fast 95.9% success rate. 81% of them were pain-free within the first week.
These patients were spared long-term drug use, the standard medical treatment. This 1949 study concluded that vitamin U treatment was more effective than medications for the same condition, as it prompted a healing response in the body that lasted, unlike medications.
Znscn Reduced The Size Of Ulcer Lesions And The Extent Of Neutrophil Infiltration
Images of tissue sections stained with haematoxylin and eosin , and PAS are shown in . Gastric lesions induced by HCl/EtOH showed significant damage of the gastric mucosal epithelium. In addition, the deep lesions revealed obvious necrosis of the mucosa together with extensive edema and submucosal infiltration of neutrophils into the stomach lining of the ulcer group as indicated in Fig. I b. Furthermore, PAS staining revealed depletion of gastric mucosal secretion in the same group of animals. Pre-treatment with ZnSCN protected the gastric mucosa of rats as demonstrated by the reduction of ulcer lesions and neutrophil infiltration. The positive PAS staining of the mucosal lining of the stomach in the groups pre-treated with the complex indicated higher levels of mucosal glycoproteins than were present in the ulcer group . These histological findings confirmed the biochemical results and again suggest that ZnSCN has gastroprotective activity.
Figure 11: Histological observations of HCl/EtOH-induced gastric mucosal damage in rats H& E staining. PAS staining of the mucus layer.Figure 12: Effect of ZnSCN on the immunohistochemical staining of Hsp70 and Bax .
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What Are Neurotrophic Ulcers
Neurotrophic ulcers occur primarily in people with diabetes, although they can affect anyone who has impaired sensation in their feet. They can be found anywhere on your feet, but they usually develop on the parts of your feet and toes that are most sensitive to weight .
Neurotrophic ulcers dont cause pain. But they can be serious if they arent treated promptly or they dont respond to treatment.
A neurotrophic ulcer might be the following colors:
- Any combination of those colors.
The thin borders of the ulcers are punched out, meaning that theyre taller than the surrounding tissues.
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